重庆市重点实验室学术交流报告——Shannon Entropy for Time-Varying Persistence of Cell Migration

报 告 人  : 刘艳平（重庆大学物理学院）

时 间:2020年11月26号（星期四）下午14 点 00 分

地 点 : 物理学院 LE705

邀 请 人  :软凝聚态物理及智能材料研究重庆市重点实验室  

报告摘要：

Cell migration, which can be significantly affected by intracellular signaling pathways (ICSP) and extracellular matrix (ECM), plays a crucial role in many physiological and pathological processes. We introduce the time-varying Shannon entropy based on the wavelet power spectrum of cellular dynamics and demonstrate its superior utility to characterize the time-dependent persistence of cell migration, which is typically resulted from complex and time-varying intra or extracellular mechanisms. We employ our approach to analyze trajectory data of in vitro cell migration regulated by distinct intracellular and extracellular mechanisms, exhibiting a rich spectrum of dynamic characteristics. Our analysis indicates that the combination of Shannon entropy and wavelet transform offers a simple and efficient tool to estimate the persistence of cell migration, which may also reflect the real-time effects of ICSP-ECM to some extent.

报告人介绍：

重庆大学物理学院在读博士生，师从刘雳宇教授，研究方向为细胞迁移动力学建模（Modeling of cell migration dynamics），并在该研究方向上发表SCI论文5篇。